This site is intended for U.S. healthcare professionals.

Visit Pfizer Medical

Menu

Close

Sign InLog Out ProductsOrderMaterialsCo-pay Cards & Patient Savings OffersRequest SamplesHospital ProductsVaccinesPatient AssistancePfizer Oncology TogetherPfizer RxPathwaysPfizer Dermatology Patient AccessExplore ContentEventsMaterialsVideosContact
Search

Menu

Close

HomeAbout
Using THROMBIN-JMI
Clinical StudiesClinical
StudiesEfficacySafety & ManufacturingSupport & OrderingSupport & OrderingMaterialsVideosOrdering InformationRequest a Representative
Full Prescribing Information including BOXED WARNING Indication
About THROMBIN-JMITHROMBIN-JMI® is a biological topical hemostatic agent that actively participates at the end of the coagulation cascade.1-3 How THROMBIN-JMI works

THROMBIN-JMI aids hemostasis by activating platelets and effecting the conversion of fibrinogen to fibrin.1 Watch the video to learn more.

Data through 2021. Denotes 5,000 IU equivalent units.THROMBIN-JMI offers a hemostatic standard of care1,5-11

In clinical trials, THROMBIN-JMI demonstrated similar efficacy and safety when compared to both recombinant human thrombin and plasma-derived human thrombin.1,5,7,9,12

See the dataLoading
Learn more about using
THROMBIN-JMI.
 Explore THROMBIN-JMI products Loading

Please see full Prescribing Information, including BOXED WARNING, for THROMBIN-JMI.

References:THROMBIN-JMI (Thrombin, Topical [Bovine] U.S.P.) [prescribing information]. New York, NY: Pfizer Inc.; 2023.Widmaier EP, Raff H, Strang KT. Hemostasis: the prevention of blood loss. In: Lange M, Wheatley CH, Schreiber F, eds. Vander’s Human Physiology: The Mechanisms of Body Function. 12th ed. New York, NY: McGraw-Hill; 2011:424-427.Oz MC, Rondinone JF, Shargill NS. Floseal Matrix: new generation topical hemostatic sealant. J Cardiac Surg. 2003;18(6):486-493.Pfizer data on file.Doria C, Fischer CP, Wood CG, Li PM, Marra S, Hart J. Phase 3, randomized, double-blind study of plasma-derived human thrombin versus bovine thrombin in achieving hemostasis in patients undergoing surgery. Curr Med Res Opin. 2008;24(3):785-794.Evaluation of an absorbable surgical hemostatic agent: Thrombi-Gel® versus Gelfoam-thrombin (control). ClinicalTrials.gov website. NCT00652314. https://clinicaltrials.gov/ct2/show/NCT00652314. Accessed July 28, 2023.Chapman WC, Singla N, Genyk Y, et al. A phase 3, randomized, double-blind comparative study of the efficacy and safety of topical recombinant human thrombin and bovine thrombin in surgical hemostasis. J Am Coll Surg. 2007;205(2):256-265.Glickman M, Gheissari A, Money S, Martin J, Ballard JL; CoSeal Multicenter Vascular Surgery Study Group. A polymeric sealant inhibits anastomotic suture hole bleeding more rapidly than Gelfoam/thrombin: results of a randomized controlled trial. Arch Surg. 2002;137(3):326-331.Minkowitz H, Navarro-Puerto J, Lakshman S, et al; Clinical Investigation Study Group on Topical Thrombin (Human) Grifols in Surgery. Prospective, randomized, phase II, non-inferiority study to evaluate the safety and efficacy of topical thrombin (human) Grifols as adjunct to hemostasis during vascular, hepatic, soft tissue, and spinal open surgery. J Am Coll Surg. 2019;229(5):497-507.e1.Schreiber MA, Neveleff DJ. Achieving hemostasis with topical hemostats: making clinically and economically appropriate decisions in the surgical and trauma settings. AORN J. 2011;94(5):S1-S20.IMS data on file.Driver VR, Hanft J, Fylling CP, Beriou JM; Autologel Diabetic Foot Ulcer Study Group. A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Ostomy Wound Manage. 2006;52(6):68-87.

To report an adverse event, please call 1-800-438-1985

Pfizer for Professionals 1-800-505-4426

This site is intended only for U.S. healthcare professionals. The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only.

© 2025 Pfizer Inc. All rights reserved.

PP-THR-USA-0576
You are now leaving Pfizer You are now leaving a Pfizer operated website. Links to all outside sites are provided as a resource to our visitors. Pfizer accepts no responsibility for the content of sites that are not owned and operated by Pfizer.
 PP-THR-USA-0464
​​​​​​​
Indication THROMBIN-JMI is topical bovine thrombin indicated to aid hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (such as suture, ligature, or cautery) is ineffective or impractical. In various types of surgeries, solutions of THROMBIN-JMI may be used in conjunction with an Absorbable Gelatin Sponge, USP for hemostasis. Please see full Prescribing Information, including BOXED WARNING for THROMBIN-JMI.
Important Safety Information

WARNING: SEVERE BLEEDING AND THROMBOSIS COMPLICATIONS

  • THROMBIN-JMI can cause fatal severe bleeding or thrombosis. Thrombosis may result from the development of antibodies against bovine thrombin. Bleeding may result from the development of antibodies against factor V. These may cross-react with human factor V and lead to its deficiency. 
  • Do not re-expose patients to THROMBIN-JMI if there are known or suspected antibodies to bovine thrombin and/or factor V.
  • Monitor patients for abnormal coagulation laboratory values, bleeding, or thrombosis.
  • Do not inject directly into the circulatory system. Because of its action in the clotting mechanism, THROMBIN-JMI can cause extensive intravascular clotting or death.
  • Do not re-expose patients to THROMBIN-JMI if there are known or suspected antibodies to bovine thrombin and/or factor V.
  • Do not administer to patients with a history of hypersensitivity to THROMBIN-JMI, its components and/or to material of bovine origin.
  • Do not use for treatment of severe or brisk arterial bleeding.
  • Allergic reactions, including anaphylactic/anaphylactoid reactions, have been reported following administration of THROMBIN-JMI.
  • Institute intensive supportive measures and treat individual symptoms. Secure the airway and establish adequate respiratory exchange.
  • THROMBIN-JMI causes thrombosis if it enters the circulatory system due to its action in the clotting system. Apply topically. DO NOT INJECT.
  • Inhibitory antibodies may develop in patients and interfere with hemostasis. Do not re-expose patients to THROMBIN-JMI if there are known or suspected antibodies to bovine thrombin and/or factor V, due to the potential for these antibodies to interfere with hemostasis. Monitor patients for abnormal coagulation laboratory values, bleeding, or thrombosis.
  • Bleeding may result from the development of antibodies against factor V. These antibodies may cross-react with human factor V and lead to human factor V deficiency.
  • Thrombosis may result from the development of antibodies against bovine thrombin.
  • Because THROMBIN-JMI may cause the formation of clots in blood vessels if it enters the bloodstream, advise patients to consult their physician if they experience leg tenderness or swelling, chest pain, shortness of breath, or difficulty speaking or swallowing.
Most common adverse reactions (incidence greater than or equal to 2%) are hypersensitivity, bleeding, anemia, post-operative wound infection, thromboembolic events, hypotension, pyrexia, tachycardia and thrombocytopenia. In another study, the most common treatment-emergent adverse reactions (experienced by >5% patients within a treatment group) were procedural pain, nausea, constipation, pruritus, muscle spasms, insomnia, pyrexia, and vomiting.Animal reproduction studies have not been conducted with THROMBIN-JMI. It is also not known whether THROMBIN-JMI can cause fetal harm when administered to a pregnant woman. THROMBIN-JMI should be given to a pregnant woman only if clearly needed.It is not known whether this drug is excreted in human milk. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for THROMBIN-JMI and any potential adverse effects on the breastfed infant from THROMBIN-JMI or from the underlying maternal condition.Safety and effectiveness in children have not been established.Please see full Prescribing Information, including BOXED WARNING, for THROMBIN-JMI.INDICATIONTHROMBIN-JMI is topical bovine thrombin indicated to aid hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (such as suture, ligature, or cautery) is ineffective or impractical.In various types of surgeries, solutions of THROMBIN-JMI may be used in conjunction with an Absorbable Gelatin Sponge, USP for hemostasis.Adapted from
USPI: THROMBIN-JMI Revised March 2024; LAB-0604-14.0Please see full Prescribing Information, including BOXED WARNING, for THROMBIN-JMI.